Past Issues
Mental Disorder Induced by
Olfactory-groove Meningioma
Carol Sheei-Meei Wang, M.D.1,2, Yen Kuang Yang, M.D.2, Hsin-Yi Lo,M.D.2, Yu Chang Hung, M.D.3, Tzung Lieh Yeh, M.D.2, Ming-JenYang, M.D., Sc.D.2
Object: We report on a case of olfactory-groove meningioma-induced mental
dysfunction, in particular, a specific meningioma-induced mood abnormality.
The relationship between the clinical presentation of the patient and the specific locale
of the tumor, the resultant mental changes for the afflicted individual following
tumor excision, and the patient's prognosis are discussed herein. Case report:
A forty-year-old female had experienced progressive depression-related symptoms
and headache for the preceding three years, such symptoms appearing to have
been precipitated by life's stresses. Her moods had appeared to have improved subsequent
to medication with an antidepressant agent for the preceding two-to-three
months prior to her presentation at our institution. At around the same time as commencing
her antidepressant medication, this patient suffered fromanosmia without
recommendation. Her psychiatric symptoms progressed with apathy, indifference,
avolition, fantastic hallucination, and poor self care for two years prior to her presentation
at our hospital. Since she visited our medical doctor, a first-stage, rightside
renal-cell carcinoma (RCC) was accidentally found and removed immediately.
However, the patient's mental condition became worse. Suspecting an organic
mental disorder, a brain MRI was performed, the results of which revealed a huge
meningioma in the olfactory groove. Mania-related symptoms appeared post tumor
excision, but her moods improved markedly after using a mood stabilizer. Conclusion:
The classical onset of olfactory-groove meningioma is insidious. Symptomatic
of something more serious than deemed to be the case by so-afflicted individuals,
both anosmia and headache are easily neglected by a patient due to their
frequent prevalence amongst individuals in a modern society. A physician might
also misinterpret this tumor's early presentations as simply a matter of patient depression
associated with certain somatic complaints, and as particularly associated
with significant life stresses and earlier RCC. To the best of our knowledge, it is
quite rare for a subject to feature, simultaneously, two different kinds of tumor
which do not appear to be related to each other, this being especially the case for
RCC and meningioma.
Key Word | olfactory-groove meningioma, depression, mania, anosmia |
---|