Past Issues

Quetiapine-associated Tardive Dyskinesia

Hsing-Kang Chen, M.D.1, Chin-Bin Yeh, M.D.1,2, Wei-Wen Lin, M.D, Ph.D.1,2,3

Objective: To report a case of tardive dyskinesia in a patient treated with
quetiapine. Case report: A 51-year-old male had been treated with antipsychitics
for 3 years, including clothiapine 40 mg/d, risperidone 2-4 mg/d, and zotepine 150
mg/d, individually. He was switched from zotepine to quetiapine 400 mg/d due to
parkinsonism, which subsided 1 week after the change, however, the TD symptoms
were subsequently noted 5 months later. These symptoms improved significantly
after discontinuation of the quetiapine, but worsened after the quetiapine (400 mg/d)
was again prescribed during admission to another hospital. In the beginning of his
latest hospitalization, all medications were discontinued because the patient’s manic
symptoms had been in full remission for at least 10 months. He was discharged 3
weeks after hospitalization with significant improvement of the TD symptoms.
Conclusion: This single case report suggests that quetiapine might be associated
with occurrence of TD symptoms although the frequency is presumably much rarer
than that of conventional antipsychotics.
Key Word antipsychotics, tardive dyskinesia, quetiapine, bipolar disorder
Editorial Committe, Taiwanese Journal of Psychiatry
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