Past Issues
Add-on Theta Burst Stimulation for
Treatment-resistant Depression with Migraine
Chih-Kuang Lin, M.D.1, Ying-Zu Huang, M.D.2, Chia-Yih Liu, M.D.1 , Ching-I Hung, M.D.1, Rou-Shayn Chen, M.D.2, Mei-Chun Hsiao, M.D.1
Background: Growing interest in using of repetitive transcranial magnetic
stimulation (rTMS) to treat neurological and psychiatric diseases is emerging. A
novel form of rTMS called theta burst stimulation (TBS) has been recently developed.
To our knowledge, little information has been reported on TBS to treat migraine.
Case report: We gave a two-week course of TBS to a 46-year-old woman
with migraine and treatment-resistant depression. The patient remained on her ongoing
antidepressant during TBS therapy. After the treatment, her depression was
improved. The scores of the Hamilton Rating Scale for Depression (HAMD), the
Hamilton Rating Scale for Anxiety (HAMA) and Beck Depression Inventory
(BDI) were decreased from the pre-treatment baselines by 25%, 21% and 19%, respectively.
According to her formal migraine diary, the intensity and frequency of
her migraine attacks were improved by 25% and 71%, respectively. Conclusion:
This case report suggests that rTMS (and specifi cally TBS) might provide a potential
nonpharmacologic therapy for patients with both depression and migraine.
stimulation (rTMS) to treat neurological and psychiatric diseases is emerging. A
novel form of rTMS called theta burst stimulation (TBS) has been recently developed.
To our knowledge, little information has been reported on TBS to treat migraine.
Case report: We gave a two-week course of TBS to a 46-year-old woman
with migraine and treatment-resistant depression. The patient remained on her ongoing
antidepressant during TBS therapy. After the treatment, her depression was
improved. The scores of the Hamilton Rating Scale for Depression (HAMD), the
Hamilton Rating Scale for Anxiety (HAMA) and Beck Depression Inventory
(BDI) were decreased from the pre-treatment baselines by 25%, 21% and 19%, respectively.
According to her formal migraine diary, the intensity and frequency of
her migraine attacks were improved by 25% and 71%, respectively. Conclusion:
This case report suggests that rTMS (and specifi cally TBS) might provide a potential
nonpharmacologic therapy for patients with both depression and migraine.
| Key Word | repetitive transcranial magnetic stimulation (rTMS), theta burst stimulation (TBS), treatment-resistant depression, migraine |
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