Past Issues

Background: Neuropsychiatric events have been reported in novel infl uenza
A (H1N1) patients treated with oseltamivir, especially in pediatric population, and
mostly in Japan. Some of these events may have lethal consequences. Case Report:
A 13-year-old boy with attention-defi cit/hyperactivity disorder had novel infl
uenza A (H1N1) infection and received oseltamivir treatment. He developed depersonalization
and derealization experiences soon after oseltamivir use, which
led to functional impairment that persisted for around 10 days. The experiences
lasted fi ve days after his stopping of oseltamivir and recovering from the infection.
The patient returned to his baseline subsequently. Conclusion: Depersonalization
and derealization are uncommon neuropsychiatric manifestations occurred after
taking oseltamivir medication in patients with infl uenza infection. A possible causal
relationship according to the Naranjo probability scale was observed. The varied
neuropsychiatric adverse events, unclear pathological mechanism, and the approach
to identify patients in a high-risk population necessitate further investigation.