Past Issues

Monoamine Oxidase A Polymorphism, Gender, and Smoking as Predictors for Treatment Respose in Olanzapine-treated patients with Schizophrenia

Ting-Sheng Chung,For-Wey Lung,Dong-Sheng Tzeng,

Objective: The aim of this study was to explore the treatment effect of olanzapine
on the polymorphisms of monoamine oxidase A (MAOA) in schizophrenia.
Method: During a 3-month period, 60 patients with schizophrenia were administered
olanzapine. Treatment response was assessed by checking for improvement
in symptoms as measured on the Positive and Negative Syndrome Scale (PANSS).
Results: The short form of MAOA demonstrated a better drug response in the dimension
of aggression. Female patients had a better response to olanzapine. Patients
who did not smoke had a better response to olanzapine in the dimension of
aggression. Conclusion: The results of this study suggest that polymorphisms of
MAOA, gender, and cigarette smoking may be three useful response predictors in
schizophrenic patients who were treated with olanzapine.
Key Word MAOA polymorphism, treatment response, olanzapine, schizophrenia
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