Past Issues

Retrospective Evaluation of Liver Function in Psychiatric Patients with Hepatitis B Viral Infection

Lien-Chung Wei, Chih-Chiang Chiu, Hung-Yu Chan, Sun-Yuan Chou, Happy Kuy-Lok Tan, Chiung-Hsu Chen

Background: Valproic acids are frequently used in patients with bipolar disorders
or other psychiatric disorders. Safety issues have been concerned to prescribe
valproic acid in patients with hepatic dysfunction due to its possible adverse
effects of hepatotoxicity. Methods: We evaluated the values of SGOT and SGPT
in 623 psychiatric inpatients who had hepatitis B infection and valproic acid
through the computer database of a psychiatric hospital. Results: Psychiatric patients
of hepatitis B carriers treated by valproic acid did not have higher levels of
liver function compared to those who were not treated by valproic acid. Conclusion:
The results of this study suggest that valproic acid use in psychiatric patients
with hepatitis B infection is safe in terms of liver function.
Key Word liver function, valproic acid, hepatitis B infection
Editorial Committe, Taiwanese Journal of Psychiatry
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