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Objective: To assess cognitive response and change in neuropsychological features in patients with Alzheimer’s disease (AD) treated with donopezil 5mg/day. Methods: Eighty patients with AD diagnosed according to DSM-TV and NINCDS-ADRDA criteria were recruited. All patients underwent evaluation of cognitive function (defined by Cognitive Ability Screening Instrument, CAST) before, and at 20- and 40- weeks after treatment. Repeated measures ANOVA was used to assess cognitive performance data. Results: There rere 39 patients who completed the study, resulting in a droppedout rate of 51%. CAST scores (p<0.0O5), recent memory (p significant improvement from baseline levels at week 20 but not at week 40 except for orientation which showed sustained improvement at week 40 (pNo information available