Past Issues

International Scientifi c Productivity on Second-generation Antipsychotic Drugs in Taiwan: A Bibliometric Study

Franciscoo López-Muñoz, Winston W. Shen, Raquel Moreno, Juan D. Molina,Concha Noriega Miguel A. Pérez-Nieto, Gabriel Rubio, Cecilio Álamo

Background: This is a bibliometric study on the scientifi c papers of secondgeneration
(atypical) antipsychotic drugs (SGAs) from Taiwan. Methods: With
the EMBASE and MEDLINE databases, we chose the published documents from
Taiwan with the descriptors of atypical*, antipsychotic*, second-generation antipsychotic*,
clozapine, risperidone, olanzapine, ziprasidone, quetiapine, sertindole,
aripiprazole, paliperidone, amisulpride, zotepine, asenapine, iloperidone
and lurasidone. We used bibliometric indicators of production and dispersion, i.e.,
Price’s law on the increased scientifi c papers, and Bradford’s law on dispersion.
We also calculated the participation index of the different countries, and correlated
those bibliometric data with some social and health data from Taiwan (such as total
per capita expenditure on health and overall volume of production in the fi eld of
Psychiatry and Neurology). Results: We downloaded 359 SGA-related original
documents published from 1993 to 2011: 29.53% of them were dealt with clinical
effi cacy and 40.11% tolerance and safety. Our study results fulfi lled Price’s law,
that scientifi c SGA papers showed exponential growth (r = 0.9601, as against an r
= 0.9305 after linear adjustment). Of SGA publications, the drugs most studied are
clozapine (89 papers), risperidone (82), aripiprazole (74), olanzapine (62), and
quetiapine (22). Division of the results into Bradford zones yielded a nucleus published
exclusively in the Progress in Neuro-Psychopharmacology and Biological
Psychiatry (56 articles). All papers from Taiwan were published in 90 different
journals, and 8 of the fi rst 10 most often published journals for Taiwanese papers
have an impact factor being greater than 2. Conclusion: The published SGA papers
from Taiwan have been growing exponentially from 1933-2011, without any
evidence of reaching a saturation point.
Key Word second-generation antipsychotics, atypical antipsychotics, bibliometry, bipolar disorder, Taiwan
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