Past Issues
Neuronal Auto-antibodies and Psychiatric Disorders
Yun-Hsiang Chen, Chia-Hsiang Chen
Neuronal auto-antibodies, if they gain access to the brain tissue, can potentially
damage the central nervous system resulting in various neuropsychiatric disorders.
Neuronal auto-antibodies are becoming increasingly recognized, and can
be categorized on the basis of cellular localizations of the antigens they target.
Antibodies that target neuronal cell-surface antigens have been identified in several
forms of encephalitis, and some associated psychiatric manifestations often
resemble those observed in patients with schizophrenia. In this article, we review
various neuronal auto-antibodies and their target antigens, and also discuss the
findings that highlight a possible etiological role of neurotransmitter-receptor antibodies
in schizophrenia.
Key Word | antigen, auto-antibody, neurotransmitter, schizophrenia |
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