Past Issues

Trazodone Is Not as Effective as Other Antidepressants in Treating a Patient with Major Depressive Disorder

Kah Kheng Goh, Weng-Kin Tam, Winston W. Shen

Background: Trazodone in clinical use is ineffective because of its sedation to let patient receive an adequate dose for treating a patient with major depressive disorder. We are report a case report to demonstrate this clinical efficacy issue in the treatment with trazodone. Case Report: A 83-year old male Taiwanese patient had suffered from MDD for six months. He did not response to the treatment of trazodone 150 mg/day for four months, but consequently, he responded to the treatment of milnacipran 100 mg/day or mirtazapine 30 mg/day. Conclusion: Psychiatrists in Taiwan should be alert to the fact that trazodone is not as effective as other antidepressants, and that trazodone should not be prescribed as a single antidepressant in treating an MDD patient.
Key Word antidepressant therapy, suicide, venlafaxine, bupropion
Editorial Committe, Taiwanese Journal of Psychiatry
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