Past Issues
Drug-induced Serotonin Syndrome
Wei-Ting Chen, Chien-Shu Wang, Ti Lu
A 43-year-old female patient with a two-year-old history of generalized anxiety disorder,
received clinic treatment regularly with daily
paroxetine 20 mg, chlorpromazine 100 mg, and
clonazepam 2 mg for more than six months.
During that time, she visited our clinic numerous
times for more prescription drug supplies with
complaints of persistent worrying, restlessness,
and sleep disturbances. She did not reveal her
medication history. She visited different clinics
every time and kept asking for more hypnotis.
Under the diagnoses of anxiety disorder and de-pressive disorder, several doctors adjusted her
medications as propranolol 10 mg BID, zolpi-dem 20 mg QHS, quetiapine 50 mg QHS, mir-tazapine 30 mg QHS, and trazodone 100 mg
QHS. One night, she took all medications from
two clinics because of her worsened insomnia.
Two hours later, she began to have anxiety, rest-lessness, sweating, and chill. Therefore, she was
sent to our emergency department with the com-plaints of insomnia, subjective fever, diaphore-sis, tremors, and agitation but with a clear con-sciousness. She denied any serious medical
history or substance abuse history.
Key Word |
---|