Past Issues
Fasting Serum Glucose Level in Unmedicated Patients with Major Depressive Disorder
Wei Hung Chang, Wei Ting Chen, Hui Hua Chang, Kao Chin Chen, I Hui Lee, Tzung Lieh Yeh, Po See Chen, Lan-Ting Lee, Yen Kuang Yang
Objectives:The study was aimed to explore whether unmedicated patients
with major depressive disorder (MDD) have poorer metabolic profiles than healthy
normal subjects.Methods:Fifty-five unmedicated MDD patients, 25 unmedi-
cated euthymic patients with a history of MDD, and 76 healthy subjects were
matched for age, sex, body mass index, and life stress, using recent life change
questionnaire. We examined the subjects’ fasting glucose and other metabolic pro-
files. Results:The results showed significant differences among MDD patients,
euthymic patients and the control group in fasting serum glucose level (p< 0.05).
Further analyzed data showed that the fasting serum glucose in MDD patients was
significantly higher than that in the healthy controls (p< 0.05), and that no signifi-
cant difference in fasting serum glucose was found between euthymic patients and
the others two study groups. Conclusion:This result might suggest that fasting
serum glucose level would be significantly different when the degrees of MDD
severity are different.
Key Word | major depressive disorder, metabolic syndrome, glucose, unmedicated, depressed patients |
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