Past Issues
Valproate-olanzapine-nifedipine Interaction Related Pedal Edema
Yu-Shi Lu, Ching-Hua Lin, Li-Shiu Chou
A 45-year-old single male patient with bipo-lar I disorder was admitted to acute ward of our
hospital due to depressive mood with irritability
for more than one month. The finding of physical
examination at admission revealed no bilateral
pedal edema under long-term usage of valproate
700 mg/day as mood stabilizer, nifedipine 30 mg/
day for essential hypertension, and allopurinol
100 mg/day for gouty arthritis before hospitaliza-tion. The results of laboratory tests for electro-lytes, renal function, liver function, chest X-ray,
and electrocardiography were also within normal
limits.
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