Past Issues
Tics Induced by Mirtazapine in a Young Patient
Yao-Wen Liu, Yueh-Ming Tai, Yu-Ming Cheng
This is a 17-year-old Asian male patient with
body weight of 65 kg. He had been admitted to
our hospital for depressive mood, insomnia, loss
of appetite, distractibility, fatigue, worthless feel-ing, suicidal ideation, and declined daily function
for two weeks. He denied any history of major
physical illness. He received mirtazapine with
daily dose of 30 mg/day alone at bed time under
the impression of major depressive disorder.
About one hour after his first receiving medicine,
this patient described to have symptoms of irre-sistible intermittent involuntary head jerking and
shoulder shrugging with the frequency about sev-eral times in a few minutes, and tic-free intervals
about seconds to minutes. He also described that
he had experienced irresistible urge before doing
the jerk-like movement with temporary relief
right after doing it. Those symptoms were gradu-ally declined and lasted within one hour without
further pharmacological management. Further
neurological examination on the next day revealed
no further abnormality, such as muscle weakness,
rigidity, tremor, or paresthesia. The patient re-ceived only one dose (30 mg) of mirtazapine on
the first day during his hospital course. We imme-diately switched mirtazapine 30 mg per night to
daily escitalopram 10 mg under the impression of
mirtazapine-induced tic attacks. Due to the high
casual relationship and patient’s discomfort, we
did not re-challenge the case with mirtazapine for
proving the relation between mirtazapine and the
emergence of tics.
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