Past Issues
Nonalcoholic Fatty Liver Disease among Long-term Hospitalized Patients with Schizophrenia in a Public Psychiatric Hospital
Tai-Chi Lee, Bo-Jian Wu, Chuan-Hsun Yu, Tso-Jen Wang
Objectives: Nonalcoholic fatty liver disease (NAFLD) is a notable chronic liver disease due to metabolic syndrome, which has yet to be
explored in long-term hospitalized patients with schizophrenia. In this study, we intended to study the prevalence of NAFLD and related risk
factors for patients with schizophrenia who were long-term hospitalized. Methods: All of 182 patients with schizophrenia were recruited
from a public psychiatric hospital in Taiwan. Abdomen ultrasonography was carried out for all patients. In addition to age and sex, covariates
including medical diagnoses (e.g., hypertension, hypertriglyceridemia, hypercholesterolemia, and diabetes), obesity, one-year cumulative
dose of antipsychotics before the entry of this study, and abnormal liver function were included in the logistic regression model. Results: The
mean age ± standard deviation (SD) was 50.3 ± 9.2 years. The mean duration ± SD of hospitalization was 8.7 ± 5.0 years. Males accounted
for 60.4% (110/182). The percentage of NAFLD was 70.8% (129/182). In multivariate logistic regression, patients’ odd ratios (OR) (95%
confidence interval [CI]) for a diagnosis of hypertriglyceridemia were 4.3 (1.11–16.7, p < 0.05) and for a finding of obesity 15.8 (3.82–65.6,
p < 0.01), were significantly to have NAFLD. But patients with chronic hepatitis B were not significant to have NAFLD (OR [95% CI] = 0.17
[0.05–0.6]). Conclusion: The prevalence of NAFLD was high in patients with long-term hospitalized patients with schizophrenia in this study.
We suggest that patients with schizophrenia and with long-term hospitalization need to receive timely, comprehensive, and prompt assessments
for the presence of NAFLD as well as that intervention for their NAFLD is mandatory for maintaining well-being and quality of life in them.
Key Word | chronic hepatitis B infection, medications for psychosis, steatosis of liver, Taiwan |
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